Journal
ADVANCED MATERIALS
Volume 24, Issue 18, Pages 2447-2452Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201200412
Keywords
telomerase; G-quadruplex; polymerase; porphyrin; graphene
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Funding
- 973 Project [2011CB936004, 2012CB720602]
- NSFC [20831003, 90813001, 20833006, 90913007]
- CAS
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Using porphyrin-functionalized graphene, we construct a PCR-free, low-cost, rapid, and electrochemiluminenscence (ECL) assay for detection of telomerase activity that has been demonstrated in six different cell lines and can be used as initial screening of G-quadruplex DNA binding agents and telomerase inhibitors. This ECL sensor shows highly sensitive for detection of telomerase with the detection limit as low as 10 HeLa cells mL(-1).
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