Journal
ADVANCED MATERIALS
Volume 24, Issue 28, Pages 3831-3837Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201103550
Keywords
gold nanoparticles; plasmonic nanobubbles; cancer; Doxil; drug resistance; laser
Categories
Funding
- National Institute of Health [R01GM094816, RO1EB012637, S10RR026399-01]
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Plasmonic nanobubbles, new multifunctional cellular nano-agents, are selectively generated in target cancer cells with a short near-infrared laser pulse. The enhanced cellular specificity and tunable transient nature of plasmonic nanobubbles provide fast, efficient and selective dual therapeutic effects: intracellular delivery of a drug and direct mechanical destruction of cells while sparing normal cells, and reduce drug dose and overcome drug-resistance of cancer cells.
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