Journal
ADVANCED MATERIALS
Volume 24, Issue 48, Pages 6484-6489Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201202225
Keywords
cationic polycarbonates; hydrogels; tunable mechanical properties; broad spectrum antimicrobial; antifouling; michael addition
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Funding
- Institute of Bioengineering and Nanotechnology (IBN)
- Biomedical Research Council
- Agency for Science, Technology and Research, Singapore
- IBM Almaden Research Center, USA
- Zhejiang University, China
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A novel class of antimicrobial cationic polycarbonate/PEG hydrogels are designed and synthesized by Michael addition chemistry. These hydrogels demonstrate strong broad-spectrum antimicrobial activities against various clinically isolated multidrug-resistant microbes. Moreover, they exhibit nonfouling properties and prevent the substrate from microbial adhesion. These antimicrobial and antifouling gels are promising materials as catheter coatings and wound dressings to prevent infections.
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