Journal
ADVANCED MATERIALS
Volume 24, Issue 28, Pages 3864-3869Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201200607
Keywords
platelets; targeted drug delivery; polymeric particles; layer-by-layer technique; GPIb; VWF domain
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Funding
- Institute for Collaborative Biotechnologies through U.S. Army Research Office [W911NF-09-0001]
- National Institutes of Health of the USA [HL-42846, HL-78784, HL-80718]
- Government of Catalonia [AGAUR FI2005, BE-2 2006]
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Platelets are a paradigm for a drug carrier in blood owing to their unique physical and biochemical properties. Here, we report the development of synthetic particles that mimic several physical features and important functional properties of platelets. These synthetic platelets have therapeutic and diagnostic applications for platelet associated disorders.
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