Journal
ADVANCED MATERIALS
Volume 24, Issue 45, Pages 6059-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201202520
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Funding
- EPSRC
- MRC Career Development Award
- Cancer Research UK [15601] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/E060609/1] Funding Source: researchfish
- Medical Research Council [G1100312] Funding Source: researchfish
- EPSRC [EP/E060609/1] Funding Source: UKRI
- MRC [G1100312] Funding Source: UKRI
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Polyacrylamide gels are cast upon a stiff support with controlled topography, resulting in a thin gel layer of variable height. The topographical profiles project a stiffness map onto the gel, resulting in controlled linear and non-linear 2D stiffness gradients. Fibroblasts, which migrate towards stiffer substrates, accumulate in areas with a gel thickness below 15 mu m.
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