4.8 Article

A Strategy for Depositing Different Types of Cells in Three Dimensions to Mimic Tubular Structures in Tissues

Journal

ADVANCED MATERIALS
Volume 24, Issue 7, Pages 890-+

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201104589

Keywords

tubes; 3D cell patterns; artificial vessels; electrospun fibers; rolling membrane

Funding

  1. Ministry of Science and Technology [2011CB933201, 2009CB930001]
  2. Chinese Academy of Sciences [KJCX2-YW-M15]
  3. National Natural Science Foundation of China [20890020, 90813032, 21025520, 51073045]

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The fabrication of tubular structures, with multiple cell types forming different layers of the tube walls, is described using a stress-induced rolling membrane (SIRM). Cell orientation inside the tubes can also be controlled by topographical contact guidance. These layered tubes precisely mimic blood vessels and many other tubular structures, suggesting that they may be of great use in tissue engineering.

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