Journal
ADVANCED MATERIALS
Volume 24, Issue 3, Pages 431-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201103458
Keywords
magnetic nanoparticles; redox response; intracellular drug delivery; endocytosis; endosomal escape
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Funding
- China Ministry of Science and Technology [2009CB930000]
- Natural Science Foundation of China [11032012, 51173216]
- Fok Ying Tung Education Foundation [121035]
- Natural Science Foundation of Chongqing Municipal Government (CSTC) [2010AB5116, JJA10056]
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A novel redox responsive controlled drug release system based on magnetic nanoparticles for efficient intracellular anticancer drug delivery is fabricated. Disulfide bonds are employed as intermediate linkers to immobilize PEI/beta-CD molecules as nanoreservoirs for drug loading onto magnetic nanoparticles. The endocytotic pathway and endosomal escape of the smart controlled drug release system is proposed.
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