Journal
ADVANCED MATERIALS
Volume 23, Issue 39, Pages 4516-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201101899
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Funding
- National Basic Research Program of China (973program) [2007CB935802]
- National Natural Science Foundation of China [30973652, 81172993]
- Key new drug creation program [2009ZX09310-006]
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The choline transporter (ChT) is used to transport choline-derivate-modified nanoparticles across the blood-brain barrier. It is demonstrated that ChT is an ideal Trojan horse. The choline-derivate-modified nanoparticles exhibit higher permeability across the brain capillary endothelial cells (BCECs) monolayer in vitro and higher gene distribution and expression in vivo.
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