Journal
ADVANCED MATERIALS
Volume 24, Issue 1, Pages 125-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201103205
Keywords
peptide sensor; cyclin A2; electrochemistry; impedance; graphene
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Funding
- 973 Project [2011CB936004, 2012CB720602]
- NSFC [20831003, 90813001, 20833006, 90913007]
- CAS
- Key Laboratory of Pesticide & Chemical Biology
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Hirao Taro Foundation of the Konan University Association for Academic Research
- Long-Range Research Initiative Project of Japan Chemical Industry Association
- Grants-in-Aid for Scientific Research [23651130, 21245040, 24655161] Funding Source: KAKEN
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Using a porphyrin-functionalized graphenemodifi ed electrode, an electrochemical impedance peptide sensor for labelfree detection of cyclin A2 has been constructed. This electrochemical sensor can not only detect protein in cancer cells but also differentiate cancer cells from normal ones. Furthermore, the assay provides the potential of using a simple electrochemical technique to estimate the effi ciency of anticancer drugs in cancer therapy.
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