Journal
ADVANCED MATERIALS
Volume 24, Issue 1, Pages 115-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201104066
Keywords
micelles; drug delivery; pH-sensitive on-off; fluorescent imaging; cancer treatment
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Funding
- National Natural Science Foundation of China [50830107, 20974129, U1032002]
- Natural Science Foundation of Guangdong Province [9351027501000003]
- Ministry of Science and Technology of China [2009AA03Z310]
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A novel multifunctional polymeric micelle bearing a pH-tunable on-off module for programmed drug release, folate for tumor targeting, and quantum dots for fl uorescent imaging is described. The micelle can turn drug release off at neutral pH whereas on inside lysosomes. QD functionalization allows a clear elucidation of pH-tunable drug release and facile visualization of in vivo delivery event.
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