4.8 Article

Controlled and Sustained Release of Drugs from Dendrimer-Nanoparticle Composite Films

Journal

ADVANCED MATERIALS
Volume 23, Issue 25, Pages 2839-+

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201004409

Keywords

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Funding

  1. NSF [CHE-0808945]
  2. IGERT [DGE-0504485]
  3. Center for Hierarchical Manufacturing [NSEC DMI-0531171]
  4. MRSEC
  5. Division Of Materials Research
  6. Direct For Mathematical & Physical Scien [820506] Funding Source: National Science Foundation

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A dendrimer-nanoparticle hybrid scaffold based on robust dithiocarbamate formation provides a controlled drug delivery system. These composite films are nontoxic and can incorporate a variety of guests, providing sustained drug release over multiple uses. The system is highly modular: the release process can be easily tuned by altering the dendrimer generation and the size of the AuNPs, generating a versatile delivery system.

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