Journal
ADVANCED MATERIALS
Volume 24, Issue 1, Pages 64-+Publisher
WILEY-BLACKWELL
DOI: 10.1002/adma.201103574
Keywords
hydrogels; cell encapsulation; regenerative medicine; biomaterials; PEG; peptides; maleimide; Michael addition
Categories
Funding
- National Institute of Health [R01-EB004496, R01-EB011566]
- National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services [HHSN268201000043C]
- National Science Foundation under the Science and Technology Center Emergent Behaviors of Integrated Cellular Systems (EBICS) [CBET-0939511]
- Georgia Tech/Emory Center for the Engineering of Living Tissues
- Atlanta Clinical and Translational Science Institute under PHS [UL RR025008]
- Center for Pediatric Healthcare Technology Innovation at Georgia Tech and Children's Hospital of Atlanta
- American Heart Association
- NASA
- National Science Foundation
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000454] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR025008] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB004496, R01EB011566] Funding Source: NIH RePORTER
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Engineered polyethylene glycolmaleimide matrices for regenerative medicine exhibit improved reaction effi ciency and a wider range of Young's moduli by utilizing maleimide crosslinking chemistry. This hydrogel chemistry is advantageous for cell delivery due to the mild reaction that occurs rapidly enough for in situ delivery, while easily lending itself to plug-and-play design variations such as incorporation of enzyme-cleavable cross-links and cell-adhesion peptides.
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