Journal
ADVANCED MATERIALS
Volume 23, Issue 48, Pages 5785-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201103463
Keywords
biomimetics; human embryonic stem cell derived cardiomyocytes; contact guidance; action potential propagation
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Funding
- Edwards Lifesciences Center for Advanced Cardiovascular Technology
- California Institute for Regenerative Medicine [RN2-00921-1]
- NIH [1DP2OD007283, R01 HL72857]
- Defense Advanced Research Projects Agency (DARPA) [N66001-1-4003]
- Space and Naval Warfare Systems Center Pacific (SPAWAR)
- Shrink Nanotechnologies Inc
- Stanford CIS
- CC Wong Foundation
- Research Grant Council [103544]
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A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment wrinkles. Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.
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