4.8 Article

Design of a Cellular-Uptake-Shielding Plug and Play Template for Photo Controllable Drug Release

Journal

ADVANCED MATERIALS
Volume 23, Issue 31, Pages 3526-+

Publisher

WILEY-BLACKWELL
DOI: 10.1002/adma.201101806

Keywords

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Funding

  1. Ministry of Science and Technology of China [2009CB930300, 2011C8606202]
  2. Trans(New)-Century Training Programme Foundation for the Talents from the Ministry of Education of China
  3. Natural Science Foundation of Hubei Province, China [2009CDA024]

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A novel template was designed for photocontrollable drug release. Multiple functional groups can be loaded and unloaded onto the template via UV irradiation. Importantly, the template can inhibit loaded drug being uptaken by normal cells. However, upon the irradiation of UV light to the target site, such as tumor tissues, the loaded drug can be released from the template quickly and thereafter endocytosed by target cells to achieve the desirable cure effect.

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