Journal
ADVANCED MATERIALS
Volume 23, Issue 41, Pages 4770-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201102263
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Funding
- Northwestern University [NCI CA060553]
- NCI CCSG [P30 CA060553]
- National Science Foundation [CMMI-0846323, CMMI-0856492]
- Center for Scalable and Integrated NanoManufacturing [DMI-0327077]
- National Center for Learning Teaching
- V Foundation
- European Commission [FP7-KBBE-2009-3]
- Northwestern Ryan Fellowship
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [0846323] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [0751621] Funding Source: National Science Foundation
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Multimodal nanodiamonds (NDs) were prepared by attaching fluorescently labeled drug-oligonucleotide conjugates and monoclonal antibodies onto the ND surface. Fluorescently labeled oligonucleotide linkers enabled the intracellular observation and quantification of resultant ND conjugates. The covalent attachment of the chemotherapeutic and targeting moiety to the ND surface significantly enhanced cellular internalization and therapeutic activity.
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