Journal
ADVANCED MATERIALS
Volume 24, Issue 1, Pages 58-+Publisher
WILEY-BLACKWELL
DOI: 10.1002/adma.201103207
Keywords
angiogenesis; patterned neovessels; methacrylic alginate; stereolithography; cell-encapsulation
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Funding
- US Army Telemedicine & Advanced Technology Research Center [W81XWH-08-1-0701]
- National Science Foundation [DMR-0847253, CBET-0939511, IGERT DGE-0965918]
- American Heart Association [0830468Z]
- Amore Pacific Corporation (South Korea)
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This study presents a living microvascular stamp that releases multiple angiogenic factors and subsequently creates functional neovessels with the same pattern as that engraved in the stamp. The stamp consists of live cells that secrete angiogenic factors, an engineered hydrogel matrix that promotes cellular expression of angiogenic factors, and a three-dimensional geometry that localizes the angiogenic factors within the pattern.
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