Journal
ADVANCED MATERIALS
Volume 22, Issue 46, Pages 5255-5259Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201002395
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Funding
- National Basic Research Program of China [2010CB934700]
- International Science & Technology Cooperation Program of China [2010DFA41170]
- National Natural Science Foundation of China [50732006]
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Hollow mesoporous silica (HMS) spheres preloaded with the anticancer drug Doxorubicin (DOX) can be synthesized by using porous CaCO3 spheres as templates (see figure). With good biocompatibility, the HMS@DOX spheres exhibit a greatly enhanced therapeutic effect towards tumor cells; this enhancement may be caused by the efficient protection of DOX and the pH-sensitive release of DOX, together with enhanced intracellular delivery.
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