Journal
ADVANCED MATERIALS
Volume 22, Issue 6, Pages 749-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200903020
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Funding
- Science and Technology Commission of Shanghai [0852nm05800]
- Program of Shanghai Subject Chief Scientist [07XD14031]
- National Natural Science Foundation of China [50772124, 50821004]
- Shanghai Institute of Ceramics [SCX 0606]
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Ultrahigh drug-loading capacity and the linear relationship between the cumulative amount of released drug and the natural logarithm of release time were discovered for the hierachically nanostructured mesoporous spheres of calcium silicate hydrate (CSH) obtained by a surfactant-free sonochemical method (see figure). During the release of loaded ibuprofen in simulated body fluid, CSH gradually transformed to hydroxyapatite.
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