4.8 Article

The Topographic Effect of Zinc Oxide Nanoflowers on Osteoblast Growth and Osseointegration

Journal

ADVANCED MATERIALS
Volume 22, Issue 43, Pages 4857-+

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201002255

Keywords

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Funding

  1. Ministry of Health & Welfare, Republic of Korea [A084132]
  2. Ministry of Education, Science and Technology [2009-0081871]
  3. KOSEF [R16-2004-004-01001-0]
  4. Korea Health Promotion Institute [A084132] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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ZnO nanoflowers prepared by a solution-based hydrothermal growth method result in effective osteoblast growth with higher DNA content, ALP activity, and adhesion strength than those on ZnO film. Furthermore, ZnO nanoflowers are tightly osseointegrated into the regenerated bones. The approach for fabricating nanoflower structures on biomaterial surfaces can be successfully exploited for various bone tissue engineering applications.

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