4.8 Article

Hydrophilic Co@Au Yolk/Shell Nanospheres: Synthesis, Assembly, and Application to Gene Delivery

Journal

ADVANCED MATERIALS
Volume 22, Issue 12, Pages 1407-+

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200903298

Keywords

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Funding

  1. National Basic Research Program of China [201008934700]
  2. Program of International ST Cooperation [S2010GR0314]
  3. National Natural Science Foundation of China [50732006, 20621061, 20671085]
  4. Partner Group of the Chinese Academy of Sciences
  5. Max Planck Society

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Co@Au yolk/shell nanospheres and linear assemblies of such are synthesized by controlled galvanic replacement reaction. The nanospheres are biocompatible, hydrophilic, and superparamagnetic, and gold nanocages can be prepared by etching. The potential applications of the nanospheres include use as nonviral gene transport vehicles, cellular optical imaging, and in vivo magnetic resonance imaging tracking during gene transfection.

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