Journal
ADVANCED MATERIALS
Volume 22, Issue 25, Pages 2818-2823Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200904235
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Funding
- A*STAR SERC [072 101 0020]
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Detecting subtle cellular activities that occur dynamically as regulated temporally and spatially by molecular machinery is of obvious importance in fundamental biology as well as in drug discovery. Additionally, it demands fast and sensitive detection modality. The emerging nanoelectronic biosensors based on nanostructured materials have shown promising potential to resolve the dynamic biological processes of living cells with high sensitivity and high temporal and spatial resolution. Here, the recent advances in the nanoelectronic biosensing of regulated secretion of biomolecules and bioelectrical activities of ion channels using carbon nanotubes and silicon nanowires are briefly reviewed. The perspectives and key issues of future development are also discussed.
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