Journal
ADVANCED MATERIALS
Volume 22, Issue 23, Pages 2556-2560Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200903933
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Funding
- National Institutes of Health
- National Institute of General Medical Sciences [GM073937]
- National Institute of Biomedical Imaging and Bioengineering [HL089764]
- National Science Foundation [ECCS-0725528, CBET-0546012]
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Reversibly crosslinked micellar nanoparticles that are capable of releasing encapsulated DNA in response to a reduction microenvironment and physiological ionic strength are synthesized for gene delivery. The dual-sensitive nanoparticles exhibit significantly enhanced complex and colloidal stability, yield more sustained DNA unpacking in cytosols, and mediate enhanced and more prolonged transgene expression for at least 10 days.
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