Journal
ADVANCED MATERIALS
Volume 22, Issue 48, Pages 5443-5462Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201001747
Keywords
-
Categories
Funding
- National Science Foundation [PMPDP2_122997]
- European Union [NMP4-SL-2009-229292]
- Swiss National Science Foundation (SNF) [PMPDP2_122997] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
Cell fate is regulated by extracellular environmental signals. Receptor specific interaction of the cell with proteins, glycans, soluble factors as well as neighboring cells can steer cells towards proliferation, differentiation, apoptosis or migration. In this review, approaches to build cellular structures by engineering aspects of the extracellular environment are described. These methods include non-specific modifications to control the wettability and stiffness of surfaces using self-assembled monolayers (SAMs) and polyelectrolyte multilayers (PEMs) as well as methods where the temporal activation and spatial distribution of adhesion ligands is controlled. Building on these techniques, construction of two-dimensional cell sheets using temperature sensitive polymers or electrochemical dissolution is described together with current applications of these grafts in the clinical arena. Finally, methods to pattern cells in three-dimensions as well as to functionalize the 3D environment with biologic motifs take us one step closer to being able to engineer multicellular tissues and organs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available