Journal
ADVANCED MATERIALS
Volume 22, Issue 47, Pages 5398-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201003162
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Funding
- Australian Research Council
- National Health and Medical Research Council (NHMRC) [487922]
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Biodegradable polymer capsules with drug-loaded multilayers were prepared through click chemistry via layer-by-layer assembly. The capsules can efficiently release incorporated drug by intracellular enzymatic degradation in both sensitive and resistant colorectal cancer cells in vitro. Endocytosis of drug-loaded capsules leads to bypass of Pgp-mediated multidrug resistance in cancer cells.
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