4.8 Article

Assemblies of Conjugated Polyelectrolytes with Proteins for Controlled Protein Photoinactivation

Journal

ADVANCED MATERIALS
Volume 22, Issue 14, Pages 1602-+

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200903716

Keywords

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Funding

  1. National Natural Science Foundation of China [20725308, 20721061]
  2. national Basic Research Program of China [2006CB806200]
  3. Major Research Plan of China [2006CB932100]

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Conjugated polyelectrolytes are used to specifically inactivate proteins under light irradiation through their assemblies with proteins by electrostatic or metal ion-mediated coordination interactions. Upon light irradiation, the polymer produces reactive oxygen species that react with and inactivate adjacent proteins. The present work adds a new dimension to the function of conjugated polymers.

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