4.8 Article

A Versatile Synthetic Extracellular Matrix Mimic via Thiol-Norbornene Photopolymerization

Journal

ADVANCED MATERIALS
Volume 21, Issue 48, Pages 5005-+

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200901808

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Funding

  1. Howard Hughes Medical Institute Funding Source: Medline
  2. NIDCR NIH HHS [R01 DE016523] Funding Source: Medline

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Step-growth, radically mediated thiol-norbornene photopolymerization is used to create versatile, stimuli-responsive poly(ethylene glycol)-co-peptide hydrogels (see image). The reaction is cytocompatible and allows for the encapsulation of human mesenchymal stem cells with a viability greater than 95%. Cellular spreading is dictated via three-dimensional biochemical photopatterning.

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