4.8 Article

Aldehyde-Amine Chemistry Enables Modulated Biosealants with Tissue-Specific Adhesion

Journal

ADVANCED MATERIALS
Volume 21, Issue 32-33, Pages 3399-+

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200900340

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Funding

  1. MIT-DuPont Alliance
  2. National Institutes of Health [R01 GM 49039]
  3. Philip Morris External Research Program

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The interfacial regions between PEG: dextran-based adhesive sealant and excised rat heart, lung, liver, and duodenum tissues exhibit three distinct domains; target tissue (red and blue), bulk material (green), and an adhesive regime interposed between the two. The variation in adhesive regime morphology when applied to different tissues provides a rational approach for the engineering of application-specific surgical sealants.

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