4.8 Article

Antimicrobial Activity of Silver Nanocrystals Encapsulated in Mesoporous Silica Nanoparticles

Journal

ADVANCED MATERIALS
Volume 21, Issue 17, Pages 1684-+

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200802646

Keywords

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Funding

  1. National Science Foundation [CHE 0809384]
  2. National Institutes of Health [AI057870]
  3. University of California (UC) Lead Campus for Nanotoxicology Training and Research
  4. National Science Foundation and the Environmental Protection [EF 0830117]
  5. Direct For Biological Sciences [0830117] Funding Source: National Science Foundation
  6. Direct For Mathematical & Physical Scien
  7. Division Of Chemistry [0809384] Funding Source: National Science Foundation
  8. Div Of Biological Infrastructure [0830117] Funding Source: National Science Foundation

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Silver nanocrystals encapsulated in mesoporous silica nanoparticles are prepared by coating hydrophobic silver nanocrystals with amphiphilic surfactants and growing mesostructured silica around the materials. The nanoparticles can be used as antimicrobial agents for both Gram-positive and -negative bacteria through oxidative dissolution of the silver nanocrystals. The surface characteristics of the silica exterior affect the binding to the bacteria and the cytotoxicity.

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