Journal
ADVANCED MATERIALS
Volume 21, Issue 1, Pages 86-90Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200800928
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Funding
- Institute of Bioengineering and Nanotechnology
- Agency for Science, Technology and Research, Singapore
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A new class of triblock oligopeptides, containing arginine for DNA binding, histidine for intracellular buffering, and hydrophobic residues for enhanced cellu lar uptake has been designed, with each block offering unique functionalities essential for efficient gene delivery. Together, these materials demonstrate strong DNA binding ability, low cytotoxicity, and significantly higher in vivo gene-transfection efficiency compared to the PEI standard.
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