Journal
ADVANCED MATERIALS
Volume 21, Issue 34, Pages 3520-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200800448
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Funding
- Core Research for Evolutional Science and Technology (CREST)
- Japan Science and Technology Agency (IST)
- Japan Society for the Promotion of Science (JSPS)
- Grants-in-Aid for Scientific Research [21659299] Funding Source: KAKEN
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A novel inorganic-organic hybrid nanocomposite is formed in situ using a simple and straightforward method. Conjugate of short interfering RNA (siRNA) duplex with poly(ethylene glycol) via a disulfide linkage (PEG-SS-siRNA) is demonstrated to regulate the crystal growth of calcium phosphate (CaP), yielding a monodispersed nanocomposite. The resultant nanocomposite can be utilized as nanocarriers for siRNA delivery.
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