Journal
ADVANCED MATERIALS
Volume 21, Issue 38-39, Pages 3910-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200901733
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Funding
- Gates Cambridge Trust
- Universities UK organizations
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A pH-responsive, endosomal membrane disruptive, metabolite-derived polyamide PP-75 is developed to deliver the MBP-Apoptin fusion protein, which induces tumor-specific apoptosis into human osteogenic sarcoma Saos-2 cells. The intracellular distribution and colocalization of MBP-Apoptin-AF647 (MA-AF649) and PP-75-FITC provide strong evidence that PP-75 both enhances uptake and facilitates cytoplasmic release of MBP-Apoptin.
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