Electrical detection of femtomolar DNA via gold-nanoparticle enhancement in carbon-nanotube-network field-effect transistors

A dramatic sensitivity enhancement in electrical detection of DNA hybridization using single-walled carbon nanotube networked field effect transistors (SNFETs) via introducing reporter DNA-Au nanoparticle (AuNP) conjugates in the hybridization step is reported. The amplified change in drain current allows to reliably determine the DNA concentration down to similar to 100 fM.