Journal
ADVANCED MATERIALS
Volume 20, Issue 3, Pages 497-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200701918
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Seeing is believing. A novel multicomponent gold nanoparticle-based nanoprobe is assembled with a thiolated DNA detection probe, horseradish peroxidase (HRP), and bovine serum albumin (BSA). In this nanoprobe, the DNA detection probe is used to construct complexes for sandwich -based DNA detection, HRP translates this hybridization event into an enzymatic catalysis-based optical signal, while and BSA acts as a non-specific blocker.
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