DNA block copolymer micelles - A combinatorial tool for cancer Nanotechnology

A novel micelle platform consisting of amphiphilic DNA block copolymers is introduced for chemotherapeutic drug delivery, allowing combinatorial testing of the drug carrier system. Oligodeoxy-nucleotide modified targeting units are clicked into the micelle corona by hybridization, allowing perfect control of surface functionalities of the nano-particle system. Cancer cells are efficiently killed when targeting units and chemotherapeutic act together within the DNA block copolymer aggregates.