Journal
ADVANCED MATERIALS
Volume 20, Issue 10, Pages 1830-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200702322
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A peptide sequence SVSVGMKPSPRP that selectively recognizes hydroxyapatite (HA) is identified by using a phage display approach. The engineered sequence exhibits chemical and structural specificity for HA over calcium carbonate and HA's amorphous calcium phosphate precursor. In situ binding to HA in a tooth cross section further demonstrates the sequence specificity and utility in nondestructive imaging applications.
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