4.8 Article

3D Cell-Migration Studies using Two-Photon Engineered Polymer Scaffolds

Journal

ADVANCED MATERIALS
Volume 20, Issue 23, Pages 4494-4498

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200801319

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Funding

  1. NSF-sponsored Materials Research Science and Engineering Center [DMR-0213805]
  2. NIH [R37 DE013033]
  3. Div Of Chem, Bioeng, Env, & Transp Sys
  4. Directorate For Engineering [0854288] Funding Source: National Science Foundation

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We use two-photon polymerization to fabricate 3D scaffolds with precise control over pore size and shape for studying cell migration in 3D. These scaffolds allow movement of cells in all directions. The fabrication, imaging, and quantitative analysis method developed here can be used to do systematic cell studies in 3D.

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