Journal
ADVANCED MATERIALS
Volume 20, Issue 5, Pages 933-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200701205
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Funding
- NIAID NIH HHS [U01 AI074579-01, U01 AI074579-03, U01 AI074579-02, U01 AI074579, U01 AI074579-04] Funding Source: Medline
- NIBIB NIH HHS [R01 EB006369-02, R01 EB006369-03, R01 EB006369-01A1, R01 EB006369-04, R01 EB006369] Funding Source: Medline
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A new room-temperature, in situ polymerization process to produce microneedles (see figure), which can encapsulate functional bioniolecules and dissolve within minutes, is presented. The dissolution rate and mechanical strength of these polymer microneedles can be tailored by changing monomer composition and microneedle geometry. Drug delivery using micrometer-scale needles that dissolve in the skin could eliminate the pain and dangers of hypodermic needle use.
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