Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 28, Issue 45, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201804081
Keywords
flexible nanoplatform; high targeting; human serum albumin; long circulation time; tumor treatment
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Funding
- State Key Basic Research Program of PRC [2014CB744504, 2014CB744501]
- NSFC of China [21603106, 81471664, 81530054]
- Natural Science Foundation of Jiangsu Province [BK20160017]
- Nature Science Foundation of Zhejiang province [LY18H180001]
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Herein, MoS2-embedded human serum albumin hollow nanocapsules (denoted MoS2/HSA) are successfully prepared via a hard-core-assisted layer-by-layer coating approach. The hollow MoS2/HSA nanocapsules possess an uniform size (280 nm), a larger hollow cavity, a low Young's modulus (222 +/- 20 MPa), excellent photothermal conversion ability, and a high drug loading capacity for doxorubicin (27 wt%). The flexible hollow MoS2/HSA nanocapsules exhibit significantly enhanced cellular uptake efficiency against breast cancer cells duo to their flexible property and targeting ability of HSA. In vivo experiments show that the flexible MoS2/HSA could reduce phagocytosis and effectively improve blood persistence and tumor accumulation. In vitro and in vivo experiments have demonstrated that the flexible MoS2/HSA based nanoplatforms effectively ablate breast cancer cells via synergistic photothermal and chemical therapy.
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