Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 28, Issue 42, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201804317
Keywords
afterglow imaging; cancer theranostics; persistent luminescence; persistent photodynamic therapy; phase change
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Funding
- NNSF of China [61525402, 61775095, 21704043]
- Jiangsu Provincial Key Research and Development Plan [BE2017741]
- Natural Science Foundation of Jiangsu Province [BK20170990, 17KJB150020]
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Herein, persistent luminescence nanoparticles (PLNPs) and photosensitizer are integrated for cancer theranostics with high specificity and without the need of continuous illumination. Specifically, ZnGa1.996O4:Cr-0.004 (PLNPs) and IR780 (photosensitizer) are encapsulated by a temperature-responsive wax-seal composed of oleic acid and hexadecanol. The seal prevents luminescence quenching and premature initiation of photodynamic therapy (PDT), until it is melted down by heat stimulus. After photothermal activation, the near-infrared afterglow offered by PLNPs provides imaging with high signal-to-background ratio because of the absence of tissue autofluorescence, as well as continuously excited photosensitizer for reactive oxygen species generation. Such theranostic nanoplatform offers multimodal imaging-guided localized cancer PDT.
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