Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 28, Issue 37, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201802605
Keywords
acrylic copolymers; bioreceptor layers; biosensors; myelin basic protein detection; OFETs
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Funding
- National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health [R21EB018426]
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Organic field-effect transistor (OFET)-based biosensors with antibody receptors are widely considered for protein antigen detection. To the authors' knowledge, there are no comparative evaluations to date of different choices for the matrix polymer to which the antibodies are attached. Herein, multiple acrylic copolymers are studied as receptor layers with myelin basic protein and its corresponding antibody as an archetypal antibody-antigen pair. Stability against multiple washing steps and the capacity for immobilizing antibodies on polymers on device surfaces with the help of fluorescein isothiocyanate-labeled antibodies are compared. Electronic detection and selectivity are also observed. The conclusions provide guidance on the selection of bioreceptor material for increasing sensitivity and process stability of OFET biosensors.
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