Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 24, Issue 42, Pages 6613-6620Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201401609
Keywords
upconversion nanoparticles; Holmium; MRI; fluorescence quenching; brain tumors
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Funding
- National Natural Science Foundation of China [51372260, 51132009, 21172043, 51102259]
- Shanghai Rising-Star Program [12QH1402500]
- Nano special program of the Science and Technology Commission of Shanghai [11nm0505000]
- Development Foundation for Talents of Shanghai [2012035]
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Multimodal bio-imaging has attracted great attention for early and accurate diagnosis of tumors, which, however, suffers from the intractable issues such as complicated multi-step syntheses for composite nanostructures and interferences among different modalities like fluorescence quenching by MRI contrast agents (e.g., magnetic iron oxide NPs). Herein, the first example of T-2-weighted MR imaging of Ho3+-doped upconversion nanoparticles (UCNPs) is presented, which, very attractively, could also be simultaneously used for upconversion luminesence (UCL) and CT imaging, thus enabling high performance multi-modal MRI/UCL/CT imagings in single UCNPs. The new finding of T-2-MRI contrast enhancement by integrated sensitizer (Yb3+) and activator (Ho3+) in UCNPs favors accurate MR diagnosis of brain tumor and provides a new strategy for acquiring T-2-MRI/optical imaging without fluorescence quenching. Unlike other multi-phased composite nanostructures for multimodality imaging, this Ho3+-doped UCNPs are featured with simplicity of synthesis and highly efficient multimodal MRI/UCL/CT imaging without fluorescence quenching, thus simplify nanostructure and probe preparation and enable win-win multimodality imaging.
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