Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 24, Issue 15, Pages 2216-2223Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201302949
Keywords
free-standing nanomembrane; layer-by-layer self-assembly; stem cell regulation; controlled release
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Funding
- NSERC
- NSERC RTI
- Manitoba Health Research Council
- Dr. Moore House Fellowship
- Manitoba Diabetes Foundation
- Manitoba Institute of Child Health
- National Basic Research Program of China [2012CB619100]
- China 863 Project [2012AA020504]
- National Natural Science Foundation of China [21304098]
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Current artificial tissue-substitutes have limited clinical applications due to unmatched complex combination of cells and extracellular matrix (ECM) as seen in native tissues. From a developmental perspective, the construction of effective biomimetic tissues is from the bottom (one-dimensional nanoparticles or two-dimensional membranes) up (three-dimensional scaffolds or more complex composite). In a hierarchical architecture, each sub-structure can be assembled in a flexible way with specific regulators and cells, which overcomes the deficiency of one-for-all scaffold. Here, a cell-compatible cell-lined layered nano-membrane is developed. Bioactive molecules are mounted on a nano-membrane and later released to its lined cell sheet. The cell-lined membrane is in a free-standing form to regulate cellular functions. The major advantage of this methodology is to provide a versatile approach to construct biomimetic tissues for clinical applications.
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