Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 25, Issue 3, Pages 421-426Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201401655
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Funding
- National Research Fund for Fundamental Key Projects [2011CB935700, 2013CB932802, 2012CB933800, 2009CB930404, 2010CB934700, 2012CB933200]
- National Natural Science Foundation [21201170, 20920102036, 21121001, 91127025, 21171171, 11290163, 21071148]
- Key Research Program of the Chinese Academy of Sciences [KJZD-EW-M01]
- China Postdoctoral Science Foundation [2013T60178, 2012M520388]
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Bio-inspired nanochannels have emerged as an interface to mimic the functionalities of biological nanochannels. One remaining challenge is to develop double-gated nanochannels with dual response, which can regulate the ion transport direction by alternately opening and closing the two gates. In this work, a bio-inspired potassium and pH responsive double-gated nanosystem is presented, constructed through immobilizing C-quadruplex and G-quadruplex DNA molecules onto the top and bottom tip side of a cigar-shaped nanochannel, respectively. It is demonstrated that the two gates of the nanochannel can be opened and closed alternately/simultaneously. This phenomenon results from the attached DNA conformational transition caused by adjusting the concentrations of potassium ion and proton. This design is believed to be the first example of dual-responsive double-gated nanosystem, and paves a new way to investigate more intelligent bio-inspired nanofluidic system.
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