Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 24, Issue 15, Pages 2188-2196Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201302901
Keywords
silk; tissue engineering; oxygen; nutrient delivery; vascularization; porous scaffolds
Categories
Funding
- NIH [NIH P41 EB002520, EY020856]
- National Science Foundation Graduate Research Fellowship Program [NSF DGE 0806676]
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In the field of regenerative medicine there is a need for scaffolds that support large, critically-sized tissue formation. Major limitations in reaching this goal are the delivery of oxygen and nutrients throughout the bulk of the engineered tissue as well as host tissue integration and vascularization upon implantation. To address these limitations, the development of a porous scaffold platform made from biodegradable silk protein that contains an array of vascular-like structures that extend through the bulk of the scaffold was previously reported. Here, the hollow channels play a pivotal role in enhancing cell infiltration, delivering oxygen and nutrients to the scaffold bulk, and promoting in vivo host tissue integration and vascularization. The unique features of this protein biomaterial system, including the vascular structures and tunable material properties, render this scaffold a robust and versatile tool for implementation in a variety of tissue engineering, regenerative medicine, and disease modeling applications.
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