Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 23, Issue 30, Pages 3719-3727Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201203726
Keywords
SERS nanoprobes; Au/Ag hollow-shell assembly; near-infrared detection; multiplex detection
Categories
Funding
- Pioneer Research Center Program through National Research Foundation of Korea
- Ministry of Education, Science, and Technology [2012-0000460]
- National Research Foundation of Korea [2011-0027888, R32-2012-000-10213-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
For the effective application of surface-enhanced Raman scattering (SERS) nanoprobes for in vivo targeting, the tissue transparency of the probe signals should be as high as it can be in order to increase detection sensitivity and signal reproducibility. Here, near-infrared (NIR)-sensitive SERS nanoprobes (NIR SERS dots) are demonstrated for in vivo multiplex detection. The NIR SERS dots consist of plasmonic Au/Ag hollow-shell (HS) assemblies on the surface of silica nanospheres and simple aromatic Raman labels. The diameter of the HS interior is adjusted from 3 to 11 nm by varying the amount of Au3+ added, which results in a red-shift of the plasmonic extinction of the Au/Ag nanoparticles toward the NIR (700-900 nm). The red-shifted plasmonic extinction of NIR SERS dots causes enhanced SERS signals in the NIR optical window where endogenous tissue absorption coefficients are more than two orders of magnitude lower than those for ultraviolet and visible light. The signals from NIR SERS dots are detectable from 8-mm deep in animal tissues. Three kinds of NIR SERS dots, which are injected into live animal tissues, produce strong SERS signals from deep tissues without spectral overlap, demonstrating their potential for in vivo multiplex detection of specific target molecules.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available