4.8 Article

A Photon-Fueled Gate-Like Delivery System Using i-Motif DNA Functionalized Mesoporous Silica Nanoparticles

Journal

ADVANCED FUNCTIONAL MATERIALS
Volume 22, Issue 22, Pages 4704-4710

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201201343

Keywords

delivery systems; i-motif DNA; mesoporous silica nanoparticles; malachite green carbinol base; photoirradiation

Funding

  1. Natural Science Foundation of China [90606003, 21175039, 20905023, 21190044]
  2. International Science & Technology Cooperation Program of China [2010DFB30300]
  3. Key Technologies Research and Development Program of China [2011AA02a114]
  4. Research Fund for the Doctoral Program of Higher Education of China [20110161110016]
  5. Hunan Provincial Natural Science Foundation
  6. Hunan Provincial Science and Technology Plan of China [10JJ7002, 2011FJ2001]

Ask authors/readers for more resources

A novel photon-fueled gate-like mesoporous silica nanoparticles (MSN)-based delivery system is reported. In this system, the malachite green carbinol base (MGCB) is immobilized on the nanochannel wall of MSN as a light-induced hydroxide ion emitter and i-motif DNA is grafted on the surface of MSN as a cap. Photoirradiation with 365 nm wavelength UV light makes MGCB molecules dissociate into malachite green (MG) cations and OH- ions, which induce the i-motif DNA to unfold into the single-stranded form due to the increase of the pH in the solution. Therefore, the pores are uncapped and the entrapped guest molecules are released. After the light is turned off, the MG cations recombine with the OH- ions and return to the MGCB forms. The pH value thus decreases and the single-stranded DNA switches back to i-motif structure to cap the pore again. Because of the photon-fueled MGCB-dependent DNA conformation changes, the i-motif DNA-gated switch can be easily operated by turning the light on or off. Importantly, the opening/closing protocol is highly reversible and a partial cargo release can be easily achieved at will. This proof-of-concept may promote the application of DNA in the controlled release and can also provide a way to design various photon-fueled controlled-release systems using a combination of some photoirradiated pH-jump systems and other kinds of pH-sensitive linkers.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available