Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 22, Issue 4, Pages 771-779Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201102191
Keywords
red-light emission; aggregation-induced emission; nanoparticles; tetraphenylethene; fluorescence bioimaging
Categories
Funding
- Singapore National Research Foundation [R-279-000-323-281]
- Research Grants Council of Hong Kong [603509, HKUST2/CRF/10]
- Temasek Defence Systems Institute of Singapore [R279-000-305-592/422/232]
- Institute of Materials Research and Engineering of Singapore [IMRE/11-1C0213]
- Innovation and Technology Commission of Hong Kong [ITP/008/09NP]
- University Grants Committee of Hong Kong [AoE/P-03/08]
- NSFC/RGC [N_HKUST620/11]
- National Science Foundation of China [20974028, 21074051]
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Light emission of 2-(2,6-bis((E)-4-(diphenylamino)styryl)-4H-pyran-4-ylidene)malononitrile (TPA-DCM) is weakened by aggregate formation. Attaching tetraphenylethene (TPE) units as terminals to TPA-DCM dramatically changes its emission behavior: the resulting fluorogen, 2-(2,6-bis((E)-4-(phenyl(4'-(1,2,2-triphenylvinyl)-[1,1'-biphenyl]-4-yl)amino)styryl)-4H-pyran-4-ylidene)malononitrile (TPE-TPA-DCM), is more emissive in the aggregate state, showing the novel phenomenon of aggregation-induced emission (AIE). Formulation of TPE-TPA-DCM using bovine serum albumin (BSA) as the polymer matrix yields uniformly sized protein nanoparticles (NPs) with high brightness and low cytotoxicity. Applications of the fluorogen-loaded BSA NPs for in vitro and in vivo far-red/near-infrared (FR/NIR) bioimaging are successfully demonstrated using MCF-7 breast-cancer cells and a murine hepatoma-22 (H22)-tumor-bearing mouse model, respectively. The AIE-active fluorogen-loaded BSA NPs show an excellent cancer cell uptake and a prominent tumor-targeting ability in vivo due to the enhanced permeability and retention effect.
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