Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 22, Issue 4, Pages 764-770Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201102582
Keywords
hollow colloidal particle; contrast agent; encapsulation
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Funding
- NIH [5DP1 OD000798]
- Washington University in St. Louis
- NSF [ECS-0335765]
- Taiwan Merit Scholarship program [NSC-095-SAF-I-564-620-TMS]
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Polystyrene (PS) hollow beads with holes on the surfaces are employed as containers for quick loading and encapsulation of a variety of contrast enhancement agents: saline solutions for thermoacoustic tomography, iodinated organic compounds for micro-computed tomography, and perfluorooctane for magnetic resonance. Because of the hole on the surface of the PS hollow bead, the contrast agent to be encapsulated could quickly enter the hollow interior via direct flow rather than slow diffusion through the wall. After loading, the hole on the surface is conveniently sealed by annealing the sample at a temperature (e.g., 95 degrees C) slightly above the glass-transition temperature of PS. In vitro methods are also used to investigate the effectiveness of encapsulation by quantifying the contrast enhancement enabled by the contrast agents.
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