Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 20, Issue 16, Pages 2644-2648Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201000780
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Funding
- Korea Ministry of Education, Science and Technology (MEST) [K20704000002-09A0500-00210, 2009-0081523, 2009-0065590, 2009-0091572]
- Korea Basic Science Institute [T29740]
- National Research Council of Science & Technology (NST), Republic of Korea [2E21760] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2008-2000183, 2006-2003764, 2009-0091572, 2010-00039] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Water-dispersed all-in-one nanoprobes composed of densely integrated peroxyoxalate fuel and a cyanine dye are formulated to optimize the nanoscopic chemiluminescence reaction. It is demonstrated that the chemiluminescent nanoformulation can generate bright near-infrared signal in response to external hydrogen peroxide that is biologically implicated with cell signaling and diseases. Successful imaging of endogenously overproduces hydrogen peroxide and indirect determination of glucose level in vivo with the chemiluminescent nanoprobes offers an opportunity for early diagnosis of diseases.
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