Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 19, Issue 21, Pages 3375-3380Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.200901051
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Funding
- Korean Government (MOEHRD) [KRF-2008-314-CO0192]
- Samsung Biomedical Research Institute [C-A8-224, OTX1070221]
- National Research Foundation of Korea [314-2008-1-C00192] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A novel method for modifying the surface of magnetic-resonance-contrasting layered gadolinium hydroxide (LGdH) is developed providing them with water- and bio-compatibility and acid-resistance, all of which are essential for medical applications. A stable colloid of exfoliated layers is synthesized by exchanging interlayer anions of LGdH with oleate ions. The delaminated layers are successively coated with phospholipids with poly(ethylene glycol) tail groups, and their effectiveness as a contrast agent for magnetic resonance imaging (MRI) is demonstrated. The adaptability of this surface modification approach for incorporating functional molecules and fabricating a fluorescent colloid of LGdH, which has the potential utility as a multimodal probe, is also demonstrated. This result provides a novel approach for expanding the applications of layered inorganic materials and developing a new class of MRI contrast agents.
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